The condition is most commonly noticed in the adolescent age group suggesting a hormonal etiology of the condition. Though the condition is less common in adulthood, approx. 4% population may continue to have the condition in their forties.
Four abnormal processes have been described in the pathogenesis of the condition:
- Higher than normal amount of sebum production (influenced by androgens)
- Excessive keratin deposition leading to comedone formation
- Colonization of the follicle by Propionibacterium acnes bacteria, and
- >Local release of pro-inflammatory chemicals in the skin.
Conventional treatment modalities aim to improve the appearance of acne and reduce scars. These include topical and/or oral treatments with antibiotics, retinoids etc. However, long term use may be associated with greater side effects. Other treatment modalities include LASER, chemical peel, microdermabrasion etc, all of which have been associated with temporary improvement of the condition. Early and aggressive treatment is advocated to lessen the overall long-term impact to individuals.
Mesenchymal stem cells (MSC) are known to have anti-inflammatory and immune-regulatory properties. MSCs when administered locally/topically and into the circulation, exert an anti-inflammatory effect thereby accelerating the healing process and reduce scarring. Platelet concentrate (platelet rich plasma-PRP) which is a rich source of growth factors has been shown to be effective in reducing acne scars.
Our protocol involves harvesting cells from the patients own body (autologous stem cells). After activation the cells are administered in the appropriate site(s). PRP administration is also done to maximize the effects of cellular therapy. Diet modifications, nutraceuticals will also be advised to achieve added benefits from the treatment.