Muscular Dystrophy

The muscular dystrophies (MD) are a group of inherited genetic conditions that gradually cause muscles to weaken, leading to an increasing level of disability.

Muscular Dystrophy Diseases

MD is progressive which means that the condition worsens over time. The different forms of MD are:

  • Duchenne muscular dystrophy.
  • Becker's muscular dystrophy.
  • Limb girdle muscular dystrophy.
  • Facioscapulohumeral muscular dystrophy.
  • Emery-Dreifuss muscular dystrophy etc...
  • MD is caused by changes/mutations in the genes responsible for the structure and functioning of a person's muscles, for eg: Duchenne Muscular dystrophy (DMD) and Becker's muscular dystrophy (BMD) are caused by mutations in gene coding for the functional protein dystrophin.

    Myotonic dystrophy (0.5-18.1 per 100,000), Duchenne muscular dystrophy (1.7-4.2) and facioscapulohumeral muscular dystrophy (3.2-4.6 per 100,000) have been found to be the most common types of muscular dystrophy. There is no specific treatment for any of the forms of muscular dystrophy. Physiotherapy, low intensity anabolic steroids, prednisone supplements may help to prevent contractures and maintain muscle tone.

    Progenitor cells are a part of the body's inbuilt repair system which are capable of differentiating into different cell types. Cellular therapy in MD has been shown to promote muscle regeneration and improve muscle function. Cellular therapy has been shown to produce healthy muscle fibers as well as reduce associated inflammation thereby improving the overall condition of the patient.

    Our protocol involves harvesting cells from the patients own body (autologous stem cells). After activation the cells are transplanted into the appropriate site. The degree of improvement achieved will depend on the stage of the condition, presence of other influencing factors and patient compliance with respect to following diet and allied therapies (physiotherapy, yoga).